Why CBD Helps You Sleep

Cannabidiol, more commonly known as CBD, continues to surge in popularity. Since its discovery by Dr. Roger Adams, an organic chemist at the University of Ilinois at Urbana-Champaign, the chemical keeps surprising people. Did you know that the discovery of CBD in 1940 happened 20 years before THC?

The chemical is said to help with epilepsy, nausea, anxiety, pain, Crohn’s Disease, Parkinson’s Disease, diabetes, depression, post-traumatic stress disorder, and more. However, it is the claim that it can help with sleep that has been attracting even more people recently.

Basic Facts About CBD

● CBD is one of 113 chemicals (“cannabinoids”) that come from the Cannabis sativa plant.
● CBD is the second largest active ingredient in cannabis (~40%) behind THC (delta-9-tetrahydrocannabinol).
● It can be obtained from both marijuana and hemp (which has a nearly non- existent THC content).
● Its molecular formula is C21H30O2 (21 carbon atoms, 30 hydrogen atoms, and 2 oxygen atoms), which makes it molecular weight 314.2246 g/mol.
● CBD boils, then vaporizes at 356°F (180°C).
● It is non-psychoactive, which means it does not cause the “high” that THC
does. This means users get the medical benefits without the anxiety, euphoria,
or time dilation that THC causes.
According to the World Health Organization, there have been no cases
reporting abuse or dependence on CBD. In human trials, they have also found
zero abuse or dependence potential.
CBD does not show up on a drug test, as long as it was made with less than 0.3% THC.

How CBD Works

CBD works by acting on the body’s endocannabinoid system (ECS). The ECS naturally produces endocannabinoids (also known as endogenous cannabinoids), which help maintain homeostasis in the body (our natural balance). Those molecules then bind with receptors, which is how the ECS knows to take action and return balance to the body.

There are two main ECS receptors:

● CB1 receptors, found mostly in the body’s central nervous system (CNS)
● CB2 receptors, found mostly in the body’s peripheral nervous system (PNS) and
specifically in immune cells.

Endocannabinoids can bind to either CB1 or CB2. The effect on the body differs depending on which endocannabinoid is binding and where the receptor is in the body.

Initially, scientists believed that those receptors were only in the brain and nerves. However, it is now known that ECS receptors are all over the body - in the skin, skeletal muscle, immune cells, bone, liver, heart, pancreas, gastrointestinal tract, blood vessels, fat tissue, and kidneys.

Once the endocannabinoids have carried out their job, they are broken down by two main enzymes.

● Fatty acid amide hydrolase, responsible for breaking down anandamide (AEA).
● Monoacylglycerol acid lipase, responsible for breaking down 2-
Arachidonoylglycerol (2-AG).

However, scientists now believe that CBD works to stop this process, unlike how THC affects the body. This also means that CBD may work to counter the effects of THC in the body.

The ECS also helps with other processes in the body, including memory, appetite, stress, pain/inflammation, metabolism, sleep, immune function, reproductive function, and mood.
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CBD for Sleep
SLEEP is led by the presence of CBN, a sedating terpene that acts synergistically with CBD to relax the body and calm the mind.

We match the primary cannabinoids with Myrcene, found in thyme, and Linalool to heighten the presence of sedating cannabis compounds.

CBD + LINALOOL =

Reduce Anxiety
Calm the Body and Mind

CBD + MYRCENE =

Sedation

So, What Is Insomnia?

According to the CDC, nearly 30% of adults in the United States don’t get the recommended seven hours of sleep a night. Sleep disorders, like insomnia, increase the risk of many different health hazards. The rate of chronic disease in people not getting enough sleep is much higher than those who do. This is especially true for diseases like type 2 diabetes, depression, obesity, and heart disease. Lack of an appropriate amount of sleep is also a factor in motor vehicle accidents as well as accidents on the job.

Insomnia can be either trouble falling asleep or trouble staying asleep, or both!

Risks of Prescription Insomnia Medications

In April 2019, the FDA issued a warning regarding multiple prescription insomnia medications. Lunesta (eszopiclone), Sonata (zaleplon), and Ambien/Intermezzo (zolpidem) now have to carry black box warnings about their risk of “complex sleep behaviors” - sleepwalking and sleep-driving. Basically, that means that a drug many people rely on to sleep may be riskier than insomnia in the first place.

The medications come with such an increased risk of dangerous side effects that guidelines published by the American Academy of Sleep Medicine suggest cognitive behavioral therapy (CBT) as primary treatment instead of medication. This is the reason why so many people are also looking at alternative treatments, like CBD.

This information is especially important considering that the United States is in the middle of an opioid epidemic.
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A Product Built For Sleep

CBD, The Body, And Sleep

One of the common schools of thought is that CBD helps to increase the body’s adenosine levels. Adenosine is a neurotransmitter that impacts the sleep-wake cycle and specifically helps to initiate sleep. Higher levels of adenosine in the body stop arousal and cause sleepiness. CBD is thought to work in the opposite way that caffeine does, promoting sleep instead of preventing it. Therefore, people suffering from insomnia are generally thought to have much lower adenosine levels than those who are able to sleep regularly.

Medical Studies on CBD’s Effect on Sleep

While there haven’t been many studies directly correlating CBD and an increase in the ability to sleep, the ones that have been done have been very promising.

One of the major studies was done on 490 participants with insomnia. It was conducted from June 2016 through May 2018. To begin, participants were asked to rate their insomnia on a scale from 1 to 10 prior to treatment, with an average score of 6.6.

The study participants were then treated with cannabis using a variety of combustion methods - joint, pipe, and vape. The potency of the THC was around 20% on average and capped at 30%. The CBD potency averaged 5.7% and was also capped at 30%.
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At the end of the study, they were asked again to rate their insomnia. On average, their rating decreased by about 4.4. The problem with this study was that the participants used the cannabis flower as a whole, and did not specifically isolate CBD. However, higher CBD potency levels were generally associated with greater reported relief of insomnia symptoms.

Another smaller study of 72 was performed to evaluate how CBD affects both anxiety and sleep. The study was only conducted for one month, and the participants were asked to fill surveys out at the beginning and the end. Each person was treated with 25 milligrams of CBD. Patients being treated for anxiety would take their dose in the morning, and those being treated for sleep would take their dose in the evening. In addition to a significant decrease in symptoms of anxiety (77%), 66% reported higher sleep scores.

What Are The Benefits Of CBD On Sleep?

While CBD has not officially been proven to help with sleep, it does reduce symptoms of anxiety, depression, and pain. And according to Joseph Maroon MD, a neuroscientist at the University of Pittsburgh, those factors are often what is inhibiting people from falling asleep in the first place. This also means that people using CBD for sleep often wake up with less pain and anxiety.

In addition, when testing CBD for the treatment of epilepsy, the largest reported side effect was fatigue. While this isn’t a direct correlation, it definitely begins to paint a picture of how it can potentially affect the body.

Although only 10% of CBD users reported taking the chemical to help with sleep, a large majority of them say it works.
When you combine all that with the fact that CBD is non-addictive, the safe choice becomes much more clear.

"I know that whenever I'm feeling stressed or just need a better night's sleep, I'll be able to find balance." 
—Alphie

"One of the more beautifully packaged CBD brands on the market today." 
—Amelia

"The BALANCE formula is the Cadillac of all tinctures." 
—Cameron

How Can CBD Be Taken?

CBD is available in a few different forms, most commonly oral capsules and tinctures. Many people find oral capsules are much easier to stick to a routine with, however. And, while tinctures may work more quickly, capsules tend to last longer overall.

Most people should start with a loading dose, which should be about 4 - 5 times the maintenance dose. This dose should be taken before bed for the first few days of use when they can decrease to their normal dose. Loading doses help the CBD build up quickly in the body, which means it can start to affect the ECS more quickly too. Usually, 10 milligrams are enough to do the trick.

In many cases, people who report that CBD doesn’t work for them just didn’t know the right way to start taking it.
However, you should always make sure to purchase your CBD products through a reputable supplier! It is important to source all products through the United States, as many products sold overseas are not coming from safe, quality companies. Look for CBD that is free of GMOs, fillers, gluten, THC, pesticides, and hormones. This means that any product you purchase should list cannabidiol as the main ingredient, followed only by ingredients necessary to hold it together (like vegetable cellulose in oral capsules).

Also make sure to verify that any CBD supplier follows FDA and USDA guidelines, Good Manufacturing Practices (GMP), tests their product regularly for contamination, and is certified by the National Sanitation Foundation. It is also best if they offer a money- back guarantee!
In Conclusion...

While there haven’t yet been many specific studies on CBD’s impact on sleep, those that have been done in conjunction with other research are glowing. Whether it directly causes sleepiness or just reduces the other factors that cause people to not be able to sleep, the end result is the same. With a current sleep epidemic, it doesn’t hurt to try!
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GQ's Best Stuff of 2019
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